Recent report at JCO shows that, in patients with H pylori positive peptic ulcers, the use of NSAIDs (Nonsteroidal anti-inflammatory drugs) reduces gastric cancer risk. Yes, a protective role against gastric cancer was found in patients using NSAID with H pylori positive gastritis – conflicting?
Maybe. ]
We know that NSAIDs plays protective role in gastric (and colon) cancer carcinogenesis, but using it as a preventive measure in gastric ulcer – that’s new… we usually defer using these drugs in patients with peptic diseases. Well, data available is telling that it is protective!!!
Evidence is still growing that inflammation plays major role in cancer development (affecting carcinogenesis processes).
More than 52 thousand patients were studied in cohorts for regular and never NSAIDs users. Never users had higher risk for gastric cancer, if they were H pylori positive: “On multivariate analysis, regular NSAID use was an independent protective factor for gastric cancer development, especially in H pylori-associated patients.”
So what to do? Take NSAID when heartburning?
Not so…. Ask your doctor about it! Ask about H pylori treatment and gastric cancer risks.
The link for the article is: http://ht.ly/2crZd
Article detais:
Chun-Ying Wu, Ming-Shiang Wu, Ken N. Kuo, Chang-Bi Wang, Yi-Ju Chen, Jaw-Town Lin
Effective Reduction of Gastric Cancer Risk With Regular Use of Nonsteroidal Anti-Inflammatory Drugs in Helicobacter Pylori–Infected Patients
Journal of Clinical Oncology, Vol 28, No 18 (June 20), 2010: pp. 2952-2957
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